Alopecia and COVID

Alopecia

No reports re Alopecia Areata 


Male Pattern Alopecia reported and felt to indicate possible role of androgens in  COVID 19


1. J Cosmet Dermatol. 2020 Apr 25. doi: 10.1111/jocd.13455. [Epub ahead of print]


Racial Variations in COVID-19 Deaths May Be Due to Androgen Receptor Genetic

Variants Associated with Prostate Cancer and Androgenetic Alopecia. Are

Anti-Androgens a Potential Treatment for COVID-19?


McCoy J(1), Wambier CG(2), Vano-Galvan S(3), Shapiro J(4), Sinclair R(5), Müller 

Ramos P(6), Washenik K(7), Andrade M(8), Herrera S(9), Goren A(1)(10).


Author information: 

(1)Applied Biology, Irvine, California, USA.

(2)Department of Dermatology, The Warren Alpert Medical School of Brown

University, Providence, Rhode Island, USA.

(3)Trichology Unit, Dermatology Department, Ramon y Cajal Hospital, IRYCIS,

University of Alcala, Madrid, Spain.

(4)Department of Dermatology, New York University Langone Medical Center, New

York City, New York, USA.

(5)Department of Medicine, University of Melbourne, Victoria, Australia.

(6)Department of Dermatology, São Paulo State University - UNESP, São Paulo,

Brazil.

(7)Ronald O. Perelman Department of Dermatology, New York University School of

Medicine, New York, New York, USA.

(8)Division of Urology, Department of Surgery and Anatomy, Ribeirao Preto Medical

School, University of Sao Paulo, Ribeirao Preto, Brazil.

(9)Infectious Diseases Department, Hospital Universitario Ramón y Cajal, Madrid, 

Spain.

(10)Department of Dermatology and Venereology, Clinical Hospital Center Sestre

Milosrdnice, Croatia, United States.


Racial disparities in COVID-19 infection rates and disease severity are due to a 

multifactorial etiology that can include socioeconomic as well as other factors. 

Nevertheless, genetic factors in different ethnic groups often contribute to

disease severity and treatment response. In particular, the frequency of genetic 

variations in the androgen receptor differs by ethnicity and gender. For example,

the increased prevalence of prostate cancer and androgenetic alopecia among

African Americans correlates with the frequency of these variants. In this

communication, we propose that androgens may be implicated in COVID-19 disease

severity. As such, special attention may need to be given to African Americans

infected by the SARS-CoV-2 virus. Finally, if a link to genetic variations in the

androgen receptor and COVID-19 disease severity can be established, it would

suggest new treatment options.


This article is protected by copyright. All rights reserved.


DOI: 10.1111/jocd.13455 

PMID: 32333494 



2. J Cosmet Dermatol. 2020 Apr 16. doi: 10.1111/jocd.13443. [Epub ahead of print]


A preliminary observation: Male pattern hair loss among hospitalized COVID-19

patients in Spain - A potential clue to the role of androgens in COVID-19

severity.


Goren A(1), Vaño-Galván S(2), Wambier CG(3), McCoy J(1), Gomez-Zubiaur A(4),

Moreno-Arrones OM(2), Shapiro J(5), Sinclair RD(6), Gold MH(7), Kovacevic M(8),

Mesinkovska NA(9), Goldust M(10), Washenik K(5)(11).


Author information: 

(1)Applied Biology, Inc., Irvine, CA, USA.

(2)Dermatology Department, Ramon y Cajal Hospital, IRYCIS, University of Alcala, 

Madrid, Spain.

(3)Department of Dermatology, The Warren Alpert Medical School of Brown

University, Providence, RI, USA.

(4)Department of Dermatology, Principe de Asturias Hospital, Alcala de Henares,

Spain.

(5)Ronald O. Perelman Department of Dermatology, New York University School of

Medicine, New York, NY, USA.

(6)Sinclair Dermatology, Melbourne, Vic., Australia.

(7)Gold Skin Care Center, Advanced Aesthetics Medical Spa, The Laser &

Rejuvenation Center, Nashville, TN, USA.

(8)Department of Dermatology and Venereology, Clinical Hospital Center Sestre

Milosrdnice, Zagreb, Croatia.

(9)Department of Dermatology, School of Medicine of the University of California 

Irvine, Irvine, CA, USA.

(10)Department of Dermatology, University Hospital Basel, Basel, Switzerland.

(11)Bosley Medical Group, Beverly Hills, CA, USA.


A preliminary observation of high frequency of male pattern hair loss among

admitted COVID-19 patients and suggest that androgen expression might be a clue

to COVID-19 severity.


© 2020 Wiley Periodicals, Inc.


DOI: 10.1111/jocd.13443 

PMID: 32301221 



3. J Am Acad Dermatol. 2020 Apr 10. pii: S0190-9622(20)30608-3. doi:

10.1016/j.jaad.2020.04.032. [Epub ahead of print]


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely 

to be androgen mediated.


Wambier CG(1), Goren A(2).


Author information: 

(1)Department of Dermatology, The Warren Alpert Medical School of Brown

University, Providence, Rhode Island. Electronic address:

carlos_wambier@brown.edu.

(2)Applied Biology, Inc, Irvine, California.


DOI: 10.1016/j.jaad.2020.04.032 

PMCID: PMC7151476

PMID: 32283245 



4. Dermatol Ther. 2020 Apr 1:e13365. doi: 10.1111/dth.13365. [Epub ahead of print]


What does androgenetic alopecia have to do with COVID-19? An insight into a

potential new therapy.


Goren A(1), McCoy J(1), Wambier CG(2), Vano-Galvan S(3), Shapiro J(4), Dhurat

R(5), Washenik K(4)(6), Lotti T(7).


Author information: 

(1)Applied Biology, Inc., Irvine, California, USA.

(2)Department of Dermatology, The Warren Alpert Medical School of Brown

University, Providence, Rhode Island, USA.

(3)Trichology Unit, Dermatology Department, Ramon y Cajal Hospital, IRYCIS,

University of Alcala, Madrid, Spain.

(4)Ronald O. Perelman Department of Dermatology, New York University School of

Medicine, New York, New York, USA.

(5)Department of Dermatology, LTM Medical College & Hospital Sion, Mumbai, India.

(6)Bosley Medical Group, Beverly Hills, California, USA.

(7)Department of Dermatology and Venereology, University of Rome "G.Marconi",

Rome, Italy.


DOI: 10.1111/dth.13365 

PMID: 32237190 


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